HQL 79 |
| カタログ番号GC10564 |
HQL 79 は、強力で選択的な経口活性ヒト造血プロスタグランジン D シンターゼ (H-PGDS) 阻害剤であり、PGD2 の合成を高度に選択的に阻害し、抗アレルギー剤として作用し、Kd は 0.8 μM、IC50 は 6 です。 μM。
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Cas No.: 162641-16-9
Sample solution is provided at 25 µL, 10mM.
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HQL-79 is a potent, selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, highly selectively inhibits the synthesis of PGD2, and acts as an anti-allergic agent, with a Kd of 0.8 μM and an IC50 of 6 μM. Shows no obvious effect on COX-1, COX-2, m-PGES, or L-PGDS[1].
HQL-79 is a competitive inhibitor against substrate PGH2 and a non-competitive one against GSH[1].
References:
[1]. Aritake K, et al. Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J Biol Chem. 2006 Jun 2;281(22):15277-86. Epub 2006 Mar 17.
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)
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