Hydroxy Pioglitazone |
| カタログ番号GC43880 |
ヒドロキシピオグリタゾン（ヒドロキシピオグリタゾン）、ピオグリタゾンの代謝産物。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 146062-44-4
Sample solution is provided at 25 µL, 10mM.
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Leriglitazone (Hydroxypioglitazone), a metabolite of pioglitazone.Leriglitazone (Hydroxypioglitazone) PioOH is a PPARγ agonist, stabilizes the PPARγ activation function-2 (AF-2) co-activator binding surface and enhances co-activator binding, affording slightly better transcriptional efficacy.Leriglitazone (Hydroxypioglitazone) binds to the PPARγ C-terminal ligand-binding domain (LBD) with Ki of 1.2 μM,induces transcriptional efficacy of the PPARγ (LBD) with EC50 of 680 nM[1].
References:
[1]. Mosure SA,et al. Structural Basis of Altered Potency and Efficacy Displayed by a Major in Vivo Metabolite of the Antidiabetic PPARγ Drug Pioglitazone. J Med Chem. 2019 Feb 28;62(4):2008-2023.
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