iBRD4-BD1 |
| カタログ番号GC71158 |
iBRD4-BD1 は選択的BRD 4臭素ドメイン阻害剤である。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2839318-17-9
Sample solution is provided at 25 µL, 10mM.
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iBRD4-BD1 has affinity and selectivity for the BET-family BRD4-BD1 with an IC50 value of 12 nM[1].
iBRD4-BD1 has affinity and selectivity for the BET-family BRD4-BD2, BRD3-BD1, BRD3-BD2, BRD2-BD1 and BRD2-BD2 with IC50 values of 16 μM, 1.0 μM , 75 μM , 280 nM and 7.1 μM, respectively[1].
iBRD4-BD1 (0-50 μM; 72 h) has cytotoxicity with an EC50 value of 2.3 μM in MM.1S cells[1].
References:
[1]. Anand Divakaran, et al. Development of an N-Terminal BRD4 Bromodomain-Targeted Degrader. ACS Med Chem Lett. 2022 Sep 29;13(10):1621-1627.
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