Indapamide-13C-d3 |
| カタログ番号GC49195 |
インダパミドの定量化のための内部標準
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2934053-07-1
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Indapamide-13C-d3 is intended for use as an internal standard for the quantification of indapamide by GC- or LC-MS. Indapamide is a carbonic anhydrase (CA) inhibitor (Kis = 0.23, 36, 10, and 13 nM for CAVII, CAIX, CAXII, and CAXIII, respectively).1 It is selective for these CAs over CAI-CAVI and CAXIV (Kis = 213->10,000 nM). Indapamide is a thiazide-like diuretic that reduces blood pressure in spontaneously hypertensive rats (SHRs).2 It also increases urinary and renovascular levels of 11,12-EET and 14,15-EET, decreases urinary levels of 11,12-DiHET and 14,15-DiHET, and reduces renal cortical malondialdehyde levels in SHRs. Formulations containing indapamide have been used in the treatment of hypertension, as well as salt and fluid retention associated with congestive heart failure.
1.Temperini, C., Cecchi, A., Scozzafava, A., et al.Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: When three water molecules and the keto-enol tautomerism make the differenceJ. Med. Chem.52(2)322-328(2019) 2.Ma, F., Lin, F., Chen, C., et al.Indapamide lowers blood pressure by increasing production of epoxyeicosatrienoic acids in the kidneyMol. Pharmacol.84(2)286-295(2013)
| Cas No. | 2934053-07-1 | SDF | |
| Canonical SMILES | ClC1=C(S(N)(=O)=O)C=C(C(NN2C([13C]([2H])([2H])[2H])CC3=C2C=CC=C3)=O)C=C1 | ||
| Formula | C15[13C]H13D3ClN3O3S | M.Wt | 369.8 |
| 溶解度 | Acetonitrile: soluble,DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.7042 mL | 13.5208 mL | 27.0416 mL |
| 5 mM | 0.5408 mL | 2.7042 mL | 5.4083 mL |
| 10 mM | 0.2704 mL | 1.3521 mL | 2.7042 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 20 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *