Ipatasertib-NH2 (Synonyms: GDC-0068-NH2; RG7440-NH2) |
カタログ番号GC63283 |
Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) は、PROTAC (INY-03-041) の標的タンパク質 AKT に対するリガンドです。 INY-03-041 は、Ipatasertib-NH2、10 炭化水素リンカー、および E3 ユビキチン リガーゼの CRBN リガンド Lenalidomide で構成されています。
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Cas No.: 1001382-14-4
Sample solution is provided at 25 µL, 10mM.
Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for target protein AKT for PROTAC (INY-03-041). INY-03-041 is composed of Ipatasertib-NH2, a ten-hydrocarbon linker, and a CRBN ligand Lenalidomide for E3 ubiquitin ligase[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. You I, et al. Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling. Cell Chem Biol. 2020 Jan 16;27(1):66-73.e7.
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