Irindalone (Lu 21-098) |
| カタログ番号GC31014 |
イリンダロン (Lu 21-098) は、新規のセロトニン 5-HT2 拮抗薬です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 96478-43-2
Sample solution is provided at 25 µL, 10mM.
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Irindalone is a novel serotonin 5-HT2 antagonist.
Irindalone causes a concentration-related inhibition of serotonin-induced contractions and shifts the serotonin curve to the right. Irindalone is more potent in inhibiting the serotonin-induced contractions. Irindalone has a similar profile in vitro, with a high affinity for serotonin 5-HT2 receptors and about a 10 times lower affinity for α1-adrenoceptors[1].
Irindalone dose dependently lowers the blood pressure in spontaneously hypertensive rats (SHR) and renal hypertensive dogs[1].
[1]. Mikkelsen EO, et al. Comparison of the effect of irindalone, a novel serotonin 5-HT2 antagonist and ketanserin on mechanical responses of rat thoracic aorta. Eur J Pharmacol. 1988 Apr 27;149(1-2):145-8.
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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