JF-NP-26 |
カタログ番号GC50497 |
JF-NP-26 は、raseglurant の不活性光ケージ誘導体であり、最初のケージ mGlu5 受容体ネガティブ アロステリック モジュレーターです。
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Cas No.: 2341841-03-8
Sample solution is provided at 25 µL, 10mM.
Caged Raseglurant . Releases raseglurant upon exposure to 405 nm (violet) light. Inhibits the effects of Quisqualate in cultured neurons when exposed to 405 nm light. Exhibits analgesic activity in pain models in vivo on photoactivation. Quantum yield = 0.18.
Font et al (2017) Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator. eLIFE 6 e23545 PMID:28395733
Average Rating: 5
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