JTE 607 dihydrochloride |
| カタログ番号GC50117 |
JTE 607 二塩酸塩は、選択性の高い炎症性サイトカイン合成阻害剤で、マウスのエンドトキシン ショックから保護します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 188791-09-5
Sample solution is provided at 25 µL, 10mM.
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Cytokine release inhibitor. Inhibits production of IL-1β, IL-8, IL-6, IL-10 and TNFα (IC50 values are 5.9, 7.3, 8.8, 9.1 and 11.0 nM, respectively) from LPS-stimulated PBMCs. Reduces proinflammatory cytokine-release and attenuates lung permeability in a rat lung injury model. Induces apoptosis in leukemia cells in vitro and prolongs survival in a mouse leukemia model.
Kakutani et al (1999) JTE-607, a novel inflammatory cytokine synthesis inhibitor without immunosuppression, protects from endotoxin shock in mice. Inflamm.Res. 48 461 PMID:10493164 |Jian (2004) JTE-607, a cytokine release blocker, attenuates acid aspiration-induced lung injury in rats. Eur.J.Pharmacol. 488 231 PMID:15044056 |Tajima et al (2010) JTE-607, a multiple cytokine production inhibitor, induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells. Cancer Sci. 101 774 PMID:20028380
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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