JZP-430 |
| カタログ番号GC34640 |
JZP-430 は、44 nM の IC50 を持つ α/β-ヒドロラーゼ ドメイン 6 (ABHD6) の強力で選択性の高い不可逆的阻害剤であり、脂肪酸アミド ヒドロラーゼ (FAAH) およびリソソーム酸性リパーゼ (LAL )。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1672691-74-5
Sample solution is provided at 25 µL, 10mM.
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JZP-430 is a potent, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) with an IC50 of 44 nM, exhibits ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL)[1]. IC50: 44 nM (ABHD6, human)[1]
[1]. Patel JZ, et al. Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors. ChemMedChem. 2015 Feb;10(2):253-65.
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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