KAT8-IN-1 |
| カタログ番号GC64990 |
KAT8-IN-1 はリジン (K) アセチルトランスフェラーゼ 8 (KAT8) 阻害剤で、IC50 はそれぞれ 141 μM (KAT8)、221 μM (KAT2B)、106 μM (KAT3B) です。
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Cas No.: 605-62-9
Sample solution is provided at 25 µL, 10mM.
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KAT8-IN-1 is a lysine (K) acetyltransferase 8 (KAT8) inhibitor, with IC50s of 141 μM (KAT8), 221 μM (KAT2B), 106 μM (KAT3B), respectively. KAT8 inhibits histone acetyltransferases (HATs), and could result in disease states, such as cancer or inflammatory diseases[1].
KAT8-IN-1 (compound 19) losses anti-oxidant activity (EC50>1 mM)[1].
[1]. Wapenaar H, et al. The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor. Eur J Med Chem. 2017 Aug 18;136:480-486.
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