KCC 07 |
| カタログ番号GC50520 |
KCC 07 は、強力で選択的な脳浸透性 MBD2 (メチル CpG 結合ドメイン タンパク質 2) 阻害剤です。 KCC 07 は、MBD2 のメチル化 DNA への結合を防ぎ、抗増殖 BAI1/p53/p21 シグナル伝達を誘導する脳特異的血管新生阻害剤 1 (BAI1) を活性化します。抗がん作用。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 315702-75-1
Sample solution is provided at 25 µL, 10mM.
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MBD2 (Methyl-CpG-binding domain protein 2) inhibitor. Prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1)/p53 signaling. Inhibits medulloblastoma (MB) cell growth in vitro and reduces tumor size in mice bearing MB xenografts. Brain penetrant.
Zhu et al (2018) BAI1 suppresses medulloblastoma formation by protecting p53 from Mdm2-mediated degradation. Cancer Cell 33 1004 PMID:29894688
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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