Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) (Synonyms: 4-Isothioureidobutyronitrile, NSC 525990) |
| カタログ番号GC32919 |
ケベトリン塩酸塩 (4-イソチオウレイドブチロニトリル塩酸塩) は、p53 の強力な活性化因子であり、TP53 野生型および変異型急性骨髄性白血病細胞でアポトーシスを誘導します。 Kevetrin は、芽細胞に対する優先的な細胞傷害活性です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 66592-89-0
Sample solution is provided at 25 µL, 10mM.
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Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Target:p53in vitro: Kevetrin activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis. Kevetrin may be effective in drug-resistant cancers with mutated p53. p53 tumor suppressor, a transcription factor regulating the expression of many stress response genes and mediating various anti-proliferative processes, is often mutated in cancer cells. in vivo: Kevetrin has demonstrated potent anti-tumor efficacy against various carcinoma xenograft models: lung, breast, colon, prostate and squamous cell carcinoma, and in a leukemia tumor model. In drug-resistant cell lines, Kevetrin has shown excellent activity, galvanizing the Company to focus on Kevetrin's development potential in this area.
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
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