L524-0366 (Synonyms: (1-(3-Chlorophenyl)-1H-1,2,3-triazol-4-yl)(thiomorpholino)methanone) |
| カタログ番号GB40256 |
L524-0366（951612-19-4）はFn14アンタゴニストです。C末端/細胞外TNF同族ドメイン（THD）において、TNF様弱誘導体のアポトーシス（TWEAK）と競合してFn14結合を阻害します（KD = 7.12μM）。特に、TWEAK-Fn14介在性NFκB活性化を抑制します。 L524-0366は、細胞毒性が50μMまでなく、10μMでTWEAK誘発性のT98G細胞移動を完全に抑制しました。 L524-0366は、TWEAK / Fn14相互作用を妨げる最初の化合物であり、新しい治療薬の開発のリード化合物として役立つ可能性があります。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 951612-19-4
Sample solution is provided at 25 µL, 10mM.
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L524-0366 (951612-19-4) is an Fn14 antagonist. Competes with TNF-like weak inducer of apoptosis (TWEAK) C-terminal/extracellular TNF homology domain (THD) for Fn14 binding (KD = 7.12 μM). It specifically inhibits TWEAK-Fn14-mediated NFκB activation. L524-0366 completely suppressed TWEAK-induced T98G cell migration (10 μM) without cytotoxicity up to 50 μM. L524-0366 is the first compound known to interfere with the TWEAK/Fn14 interaction and may serve as a lead compound for the development of new therapeutics.
| Cas No. | 951612-19-4 | SDF | |
| 同義語 | (1-(3-Chlorophenyl)-1H-1,2,3-triazol-4-yl)(thiomorpholino)methanone | ||
| Formula | C13H13ClN4OS | M.Wt | 308.79 |
| 溶解度 | DMSO: 25 mg/ml (80.96 mM), Sonication is recommended. | Storage | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.2384 mL | 16.1922 mL | 32.3845 mL |
| 5 mM | 0.6477 mL | 3.2384 mL | 6.4769 mL |
| 10 mM | 0.3238 mL | 1.6192 mL | 3.2384 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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