Laminaran |
| カタログ番号GC39259 |
ラミナランは β-1-3-グルカンであり、Eisenia Bicyclis 由来の Dectin-1 の典型的なリガンドであり、強力な免疫調節、放射線防護、および抗がん作用があります。ラミナランは β で構成されています。 (1→3)-グルカンと β (1→6)-分岐し、β を切断するラミナリナーゼ (EC 3.2.1.6) などの酵素によって触媒されます。 (1→3) 債券。ラミナランは、癌免疫療法で使用するための有望な免疫刺激分子です。
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Cas No.: 9008-22-4
Sample solution is provided at 25 µL, 10mM.
Laminaran is a neutral water-soluble β-1-3-glucan and a typical ligand for Dectin-1 isolated from the brown alga D. dichotoma, has potent immunomodulating, radioprotective, and anticancer activities[1]. Laminaran is made up of β (1→3)-glucan with β (1→6)-branches and can be catalyzed by enzymes such as laminarinase (EC 3.2.1.6) that breaks the β (1→3) bonds[2]. Laminaran is a promising immune stimulatory molecule for use in cancer immunotherapy[3].
[1]. Malyarenko OS, et al. Laminaran from brown alga Dictyota dichotoma and its sulfated derivative as radioprotectors and radiosensitizers in melanoma therapy.Carbohydr Polym. 2019 Feb 15;206:539-547. [2]. Laminaran [3]. Song K, et al. Laminarin promotes anti-cancer immunity by the maturation of dendritic cells.Oncotarget. 2017 Jun 13;8(24):38554-38567.
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