LAP (trifluoroacetate salt) |
カタログ番号GC90564 |
抗ウイルスペプチド
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
Lupus autoantigen peptide (LAP) is an antiviral peptide derived from La, an autoantigen found in patients with systemic lupus erythematosus (SLE), that corresponds to amino acids 11-28 of La.1 It inhibits the interaction between the hepatitis C virus (HCV) 5’-UTR and internal ribosome entry site (IRES) trans-acting factors (ITAFs), including polypyrimidine tract-binding protein (PTB) and poly(rC)-binding protein 2 (PCBP2).2 LAP (60 µM) inhibits HCV IRES-mediated translation in a reporter assay using Huh7 cells, an effect that can be reversed by recombinant PTB and PCBP2.1,2
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