Latanoprost (free acid) (Synonyms: LatFA, 17phenyl13,14dihydro trinor Prostaglandin F2α, PhXA85) |
| カタログ番号GC41229 |
プロスタグランジン (PG) F2α の類似体であるラタノプロスト (遊離酸) は、FP-PG 受容体を特異的に活性化する選択的プロスタノイド受容体 (FP) アゴニストです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 41639-83-2
Sample solution is provided at 25 µL, 10mM.
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Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Latanoprost is an isopropyl ester, a prodrug form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as an FP receptor ligand for the human recombinant FP receptor. Latanoprost is the isopropyl ester of a PGF2α analog containing an aromatic group (17-phenyl) in the ω-chain. Lat-FA is the corresponding carboxylic acid of this analog. Lat-FA is a potent FP receptor agonist with an EC50 of 3.6 nM for human FP receptors, which is twice the potency of PGF2α. The efficacy of PG analog esters for the treatment of glaucoma correlates closely with the FP receptor binding affinity of the free acid. However, Lat-FA is more irritating and less effective than the prodrug latanoprost when applied directly to the eyes of human glaucoma patients.
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