LCL521 dihydrochloride (1,3DMG-B13 dihydrochloride) |
| カタログ番号GC34168 |
LCL521 二塩酸塩 (1,3DMG-B13 二塩酸塩) は、酸性セラミダーゼ (ACDase) 阻害剤です。 LCL521 は、リソソーム酸性スフィンゴミエリナーゼ (ASMase) も阻害します。
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Cas No.: 1226759-47-2
Sample solution is provided at 25 µL, 10mM.
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LCL521 dihydrochloride (1,3DMG-B13 dihydrochloride) is an acid ceramidase (ACDase) inhibitor. LCL521 also inhibits the lysosomal acid sphingomyelinase (ASMase).
LCL521 (1 µM) acts as a potent inhibitor of cellular ACDase activity, whereas 10 µM LCL521 has an additional, decreased affect on the α-form of this enzyme. LCL521 (10µM) causes a time-dependent (1 hours and 5 hours) decrease of the α-ACDase form in MCF7 cells[1].
[1]. Bai A, et al. Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs. Bioorg Med Chem. 2014 Dec 15;22(24):6933-44.
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