LEI-106 |
| カタログ番号GC44049 |
LEI-106 は、強力なデュアル sn-1-ジアシルグリセロール リパーゼ α (DAGL-α)/ABHD6 阻害剤であり、DAGL-α の IC50 は 18 nM、ABHD6 の Ki は 0.8 μM です。
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Cas No.: 1620582-23-1
Sample solution is provided at 25 µL, 10mM.
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In humans, two forms of diacylglycerol lipase, DAGLα and DAGLβ, generate the endocannabinoid 2-arachidonoyl glycerol by attacking DAG at the sn-1 position. LEI-106 is a potent in vitro inhibitor of sn-1 DAGLα (IC50 = 18 nM). It blocks the hydrolysis of sn-1-oleoyl-2-AG, the natural substrate of DAGLα, with a Ki value of 0.7 µM. LEI-106 inhibits the hydrolysis of 2-AG by the monoacylglycerol lipase ABHD6 in mouse brain membrane homogenates and in HEK293T cell membrane preparations (Ki = 0.8 µM).
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