Lenalidomide-OH |
| カタログ番号GC60223 |
レナリドマイド-OH は、E3 ユビキチン リガーゼのセレブロン (CRBN) リガンド レナリドマイドの類似体であり、CRBN タンパク質の動員に使用されます。レナリドマイド-OH は、リンカーによってタンパク質のリガンドに結合して、PROTAC BTK デグレーダー SJF620 などの PROTAC を形成できます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1416990-08-3
Sample solution is provided at 25 µL, 10mM.
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Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BTK degrader SJF620 [1].
Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
[1]. Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.
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