[Leu31,Pro34] Neuropeptide Y (human) (trifluoroacetate salt) (Synonyms: Leu31,Pro34 NPY) |
| カタログ番号GC41744 |
[Leu31,Pro34] ニューロペプチドY（NPY）は、人間のNPY受容体Y1およびY5のKi値がそれぞれ0.11および0.17 nMであり、マカクザルの受容体ではそれぞれ0.08および0.18 nMです。
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![[Leu31,Pro34] Neuropeptide Y (human) (trifluoroacetate salt) 化学構造](/media/struct/GC4/GC41744.png "[Leu31,Pro34] Neuropeptide Y (human) (trifluoroacetate salt) 化学構造")
Sample solution is provided at 25 µL, 10mM.
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[Leu31,Pro34] Neuropeptide Y (NPY) is an agonist of the NPY receptors Y1 and Y5 with Ki values of 0.11 and 0.17 nM, respectively, for human and 0.08 and 0.18 nM, respectively, for rhesus monkey receptors. It reduces forskolin-induced cAMP accumulation in L-M(TK-) cells expressing human and rat Y4 receptors (EC50s = 29.5 and 2.95 nM, respectively). It also binds to rhesus monkey Y2 and mouse Y6 receptors (Kis = 410 and 9.7 nM, respectively). In vitro, [Leu31,Pro34] NPY increases cellular protein mass by 25% in rat ventricular cardiomyocytes when used at a concentration of 10 nM. In vivo, [Leu31,Pro34] NPY (0.7-7 nmol, i.c.v.) increases food intake in rats.
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