LIT-001 |
| カタログ番号GC38922 |
LIT-001 は、最初の非ペプチド性オキシトシン受容体 (OT-R) アゴニストです (EC50=55 nM; Ki=226 nM)。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2245072-21-1
Sample solution is provided at 25 µL, 10mM.
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LIT-001 is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM). LIT-001 improves social interaction in a mouse model of autism[1].
In vitro signaling experiments, LIT-001 is a nonbiased OT-R agonist on the two main signaling pathways of this receptor, with minor antagonist effect on V1a and agonist effect on V1b receptors, observed at high concentrations only[1].
LIT-001 (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD )[1]. Animal Model: Oprm1-/- mice (bred in house on a 50% 129SVPas-50% C57BL/6J hybrid background)[1]
[1]. Frantz MC, et al. LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism. J Med Chem. 2018 Oct 11;61(19):8670-8692.
Average Rating: 5 (Based on Reviews and 5 reference(s) in Google Scholar.)
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