LN6023 (hydrochloride) |
| カタログ番号GC91786 |
LN6023 is an agonist of chemokine (C-X-C motif) receptor 7 (CXCR7).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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LN6023 is an agonist of chemokine (C-X-C motif) receptor 7 (CXCR7).[1] It induces β-arrestin recruitment in a reporter assay using HEK293T cells expressing human CXCR7 (EC50 = 3.5 µM) but not in HEK293T cells expressing human CXCR4. LN6023 (100 µM) reduces surface levels of P-selectin in isolated and washed human platelets.
References:
[1].Bayrak, A., Mohr, F., Kolb, K., et al.Discovery and development of first-in-class ACKR3/CXCR7 superagonists for platelet degranulation modulationJ. Med. Chem.65(19)13365-13384(2022).
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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