Lometrexol hydrate (Synonyms: DDATHF, (6R)-Dideazatetrahydrofolate) |
| カタログ番号GC39820 |
ロメトレキソール (DDATHF) 水和物、抗プリン葉酸拮抗薬は、グリシンアミド リボヌクレオチド ホルミルトランスフェラーゼ (GARFT) の活性を阻害できますが、検出可能なレベルの DNA 鎖切断を誘発しません。ロメトレキソール水和物は、de novo プリン合成をさらに阻害し、異常な細胞増殖とアポトーシス、さらには細胞周期の停止を引き起こす可能性があります。ロメトレキソール水和物には抗がん作用があります。ロメトレキソール水和物は、強力なヒト セリン ヒドロキシメチルトランスフェラーゼ 1/2 (hSHMT1/2) 阻害剤でもあります。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1435784-14-7
Sample solution is provided at 25 µL, 10mM.
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Lometrexol hydrate (DDATHF hydrate), an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol hydrate can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol hydrate has anticancer activity[1][2].
[1]. Xu L, et al. The effect of inhibiting glycinamide ribonucleotide formyl transferase on the development of neural tube in mice. Nutr Metab (Lond). 2016 Aug 23;13(1):56. [2]. Julie L Bronder, et al. Antifolates Targeting Purine Synthesis Allow Entry of Tumor Cells Into S Phase Regardless of p53 Function. Cancer Res. 2002 Sep 15;62(18):5236-41.
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