LY-3381916 (Synonyms: IDO1-IN-5) |
カタログ番号GC33287 |
LY-3381916 は、IDO1 活性の強力で選択的な脳浸透型阻害剤であり、成熟したヘム結合 IDO1 ではなく、ヘムを欠くアポ IDO1 に結合します。
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Cas No.: 2166616-75-5
Sample solution is provided at 25 µL, 10mM.
LY-3381916 is a potent, selective and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1[1].
LY-3381916 (up to 100 µM) shows no obvious agonism of aryl hydrocarbon receptor (AHR)[1].
[1]. Frank C. Dorsey, et al. Abstract 5245: Identification and characterization of the IDO1 inhibitor LY3381916. Cancer Research. 2018, 78(13).
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