LY223982 (Synonyms: CGS 23131,SKF 107324) |
| カタログ番号GC10189 |
LY223982 はロイコトリエン B4 受容体の強力かつ特異的な阻害剤であり、LTB4 受容体への [3H]LTB4 結合に対する IC50 は 13.2 nM です。
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Cas No.: 117423-74-2
Sample solution is provided at 25 µL, 10mM.
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LY223982 is a potent and specific inhibitor of leukotriene B4 receptor, with an IC50 of 13.2 nM against [3H]LTB4 binding to LTB4 receptor.
LY223982 is a potent and specific inhibitor of leukotriene B4 (LTB4) receptor, with an IC50 of 13.2 nM against [3H]LTB4 binding to LTB4 receptor. LY223982 is also a potent antagonist of the aggregation of human neutrophils by LTB4 (IC50, 100 nM)[1].
LY223982 inhibits transient leukopenia induced in rabbits with LTB4 (ED50, 3 mg/kg) but not with FMLP, and shows no agonist activity in any of the test systems[1].
References:
[1]. Jackson WT, et al. Specific inhibition of leukotriene B4-induced neutrophil activation by LY223982. J Pharmacol Exp Ther. 1992 Dec;263(3):1009-14.
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