LY293111 (Synonyms: Etalocib; VML 295) |
| カタログ番号GC44096 |
LY293111 (LY293111) は経口活性ロイコトリエン B4 受容体拮抗薬で、[3H]LTB4 の結合を 25 nM の Ki で阻害します。
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Cas No.: 161172-51-6
Sample solution is provided at 25 µL, 10mM.
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Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from the 5-lipoxygenase pathway of arachidonic acid metabolism and is an important mediator of the inflammatory process. LY293111 is a potent antagonist of the leukotriene B4 (LTB4) receptor, BLT1, that inhibits the specific binding of radiolabeled-LTB4 to isolated human neutrophils with an IC50 value of 17.6 nM and inhibits the LTB4-induced chemotaxis of human neutrophils with an IC50 value of 6.3 nM. LY293111 inhibits growth of MiaPaCa-2 and AsPC-1 human pancreatic cancer cells in vitro (250-1,000 nM) and subcutaneous xenografts in athymic mice (250 mg/kg/day), inducing apoptosis and S-phase arrest.
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