Marstacimab |
| カタログ番号GC72427 |
Marstacimab (pf-06741086)は抗組織因子経路阻害(tfpi)モノクローナル抗体です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1985638-39-8
Sample solution is provided at 25 µL, 10mM.
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Marstacimab (20, 50 and 100 nmol/L) decreases rotational thromboelastometry (ROTEM) corn trypsin (CT) of the whole blood that obtained from haemophilia participants[1].
Marstacimab (16 μg/mL) decreases the lag time and increases thrombin generation of human nonhemophilic plateletpoor plasma samples in vitro[2].
Marstacimab (16 μg/mL) increases the peak thrombin in both hemophilia A and hemophilia B plasma samples in vitro[2].
Marstacimab (0.5 mg/kg; i.v., once) does not affect the blood flow situation in mouse acute bleeding models[2].
References:
[1]. Patel-Hett S, et al. Marstacimab, a tissue factor pathway inhibitor neutralizing antibody, improves coagulation parameters of ex vivo dosed haemophilic blood and plasmas. Haemophilia. 2019 Sep;25(5):797-806.
[2]. Pittman DD, et al. Hemostatic efficacy of marstacimab alone or in combination with bypassing agents in hemophilia plasmas and a mouse bleeding model. Res Pract Thromb Haemost. 2022 Mar 16;6(2):e12679.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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