MDNI-caged-L-glutamate (Synonyms: MDNI-glu) |
| カタログ番号GC50263 |
MDNI-ケージド-L-グルタミン酸 (MDNI-glu) は、主要な興奮性アミノ酸である L-グルタミン酸の生物学的に不活性な感光性誘導体です。
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Cas No.: 864085-92-7
Sample solution is provided at 25 µL, 10mM.
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Rapidly and efficiently releases glutamate when photolysed (350 - 365 nm excitation). Water soluble and stable at neutral pH, and pharmacologically inactive at neuronal glutamate receptors (up to 200 μM). 5.5 times more photosensitive than MNI-caged L-glutamate . Laser activation of MDNI-glu evokes a rapid increase in intracellular Ca2+ concentration in astrocytes.
Fedoryak et al (2005) Synthesis of a caged glutamate for efficient one- and two-photon photorelease on living cells. Chem. Commun. (Camb.) 7 3664 PMID:16027904 |Papageorgiou et al (2005) Synthetic and photochemical studies of substituted 1-acyl-7-nitroindolines. Photochem.Photobiol.Sci. 4 887 PMID:16252044 |Popovic et al (2015) Electrical behaviour of dendritic spines as revealed by voltage imaging. Nat.Commun. 6 8436 PMID:26436431
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