Metaxalone-d6 (Synonyms: AHR438-d6; NSC170959-d6)

Metaxalone-d₆ is intended for use as an internal standard for the quantification of metaxalone by GC-or LC-MS. Metaxalone is a skeletal muscle relaxant.^1,2 It inhibits the proliferation of, and induces apoptosis in, RAW 264.7 cells in vitro when used at concentrations ranging from 1 to 100 µM.² Metaxalone also reduces LPS-induced increases in COX-1, COX-2, and NF-kB levels and inhibits LPS-induced production of TNF-α, IL-6, and prostaglandin E₂ in RAW 264.7 cells. Formulations containing metaxalone have been used in the treatment of lower back pain.

1.Chou, R., Peterson, K., and Helfand, M.Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: A systematic reviewJ. Pain Symptom Manage.28(2)140-175(2004) 2.Yamaguchi, M., and Levy, R.M.Metaxalone suppresses production of inflammatory cytokines associated with painful conditions in mouse macrophages RAW264.7 cells in vitro: Synergistic effect with β-caryophylleneCurr. Mol. Med.20(8)643-652(2020)