Mildronate (hydrate) (Synonyms: Meldonium, MET88, Quaterine, THP) |
| カタログ番号GC44196 |
ミルドロネート (水和物) (メルドニウム二水和物) は、BBOX1 および OCTN2 を強力に阻害することにより、心保護薬として機能します。
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Cas No.: 86426-17-7
Sample solution is provided at 25 µL, 10mM.
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Mildronate is a structural analog of γ-butyrobetaine (γBB), an intermediate in the biosynthesis of carnitine. It blocks carnitine synthesis by inhibiting γBB hydroxylase (IC50 = 62 µM) and, less potently, carnitine acetyltransferase (Ki = 1.6 mM). Through these actions, mildronate reduces the levels of free carnitine and long chain acyl carnitine. This leads to suppressed fatty acid metabolism and mitochondrial uncoupling during oxidative conditions, resulting in cardioprotective and neuroprotective effects. Mildronate also improves cognition and reduces amyloid-β pathology in a mouse model of Alzheimer's disease.
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