MK-0608 |
カタログ番号GC61071 |
MK-0608 は、サブゲノム レプリコン アッセイで EC50 が 0.3 μM (EC90=1.3 μM) である、in vitro での HCV 複製の強力な経口投与可能な阻害剤です 。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 443642-29-3
Sample solution is provided at 25 µL, 10mM.
MK-0608 is a potent and orally bioavailable inhibitor of HCV replication in vitro with an EC50 of 0.3 μM (EC90=1.3 μM) in the subgenomic-replicon assay[1].
Oral dosing of MK-0608 results in a potent antiviral effect. In preclinical pharmacokinetic experiments with rats, dogs, and rhesus monkeys, MK-0608 demonstrates good to excellent oral bioavailability (50 to 100%) and long plasma half-lives in dogs and rhesus macaques (9 and 14 h, respectively)[1]. Animal Model: The HCV-infected chimpanzees[1]
[1]. Carroll SS, et al. Robust antiviral efficacy upon administration of a nucleoside analog to hepatitis C virus-infected chimpanzees. Antimicrob Agents Chemother. 2009 Mar;53(3):926-34.
Average Rating: 5
(Based on Reviews and 7 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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