ML 145 |
| カタログ番号GC17174 |
ML 145 は、選択的かつ競合的なヒト GPR35/CXCR8 アンタゴニストであり、IC50/EC50 は 20.1 nM です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1164500-72-4
Sample solution is provided at 25 µL, 10mM.
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ML 145 is a selective GPR35/CXCR8 antagonist with an IC50/EC50 of 20.1 nM, but not for the related GPR55 orphan receptor[1]. GPR35 is expressed by various cells of the immune system and it may has potential as a therapeutic target in inflammatory disease[2].
References:
[1]. Heynen-Genel S, et al. Selective GPR35 Antagonists - Probes 1 & 2. National Center for Biotechnology Information (US); 2010-2010 Feb 28.
[2]. Binti Mohd Amir NAS, et al. Evidence for the Existence of a CXCL17 Receptor Distinct from GPR35. J Immunol. 2018 Jul 15;201(2):714-724.
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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