ML318 |
カタログ番号GC62000 |
ML318 は、PvdQ アシラーゼのビアリール ニトリル阻害剤であり、アシル結合部位に結合することにより、IC50 は 20 nM です。
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Cas No.: 1610516-67-0
Sample solution is provided at 25 µL, 10mM.
ML318 is a biaryl nitrile inhibitor of PvdQ acylase with an IC50 of 20 nM by binding in the acyl-binding site. ML318 inhibits P. aeruginosa (PAO1) with an IC50 of 19 μM. ML318 prevents pyoverdine production and limits the growth of P. aeruginosa under iron-limiting conditions[1].
[1]. Jacqueline M Wurst, et al. Identification of inhibitors of PvdQ, an enzyme involved in the synthesis of the siderophore pyoverdine. ACS Chem Biol. 2014 Jul 18;9(7):1536-44.
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