MT1 |
| カタログ番号GC61097 |
MT1 は BET ブロモドメインの二価化学プローブであり、BRD4 の IC50 は 0.789 nM です(1)。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2060573-82-0
Sample solution is provided at 25 µL, 10mM.
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MT1 is a bivalent chemical probe of BET bromodomains, with an IC50 of 0.789 nM for BRD4(1)[1].
MT1 (100 nM, 24 h) significantly induces apoptosis via caspase-3 and PARP in MV4;11 cells[1]. Western Blot Analysis[1] Cell Line: MV4;11 cells[1].
MT1 (44.2 and 22.1 µmol/kg, ip daily, for 14 days) significantly delayed leukemia progression in mice (Mus musculus) compared to JQ1[1].MT1 exhibits terminal t1/2 of 2.70 h in mice[1]. Animal Model: Leukemia xenograft models[1].
[1]. Minoru Tanaka, et al. Design and characterization of bivalent BET inhibitors. Nat Chem Biol. 2016 Dec;12(12):1089-1096.
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