N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]-4-pyridinecarboxamide (Synonyms: Nec2/Hec1 Inhibitor) |
| カタログ番号GC49568 |
抗がん作用を持つINH1の誘導体
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![N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]-4-pyridinecarboxamide 化学構造](/media/struct/GC4/GC49568.png "N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]-4-pyridinecarboxamide 化学構造")
Cas No.: 560103-80-2
Sample solution is provided at 25 µL, 10mM.
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N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]-4-pyridinecarboxamide is a derivative of INH1 with anticancer activity.1 It is cytotoxic to MDA-MB-231, MDA-MB-488, HeLa, and K562 cells (IC50s = 1.1, 3.4, 1.6, and 1.2 µM, respectively).
1.Qiu, X.-L., Li, G., Wu, G., et al.Synthesis and biological evaluation of a series of novel inhibitor of Nek2/Hec1 analoguesJ. Med. Chem.52(6)1757-1767(2009)
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