N-(Amino-PEG4)-N-Biotin-PEG4-acid |
| カタログ番号GC66805 |
N-(Amino-PEG4)-N-Biotin-PEG4-acid は、ビオチン標識された PEG ベースの PROTAC リンカーで、PROTAC の合成に使用できます。
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Cas No.: 2100306-84-9
Sample solution is provided at 25 µL, 10mM.
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N-(Amino-PEG4)-N-Biotin-PEG4-acid is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.
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