N-Desethyl amodiaquine-d5 dihydrochloride |
| カタログ番号GC70614 |
N-Desethyl amodiaquine-d5 dihydrochlorideは重水素標識N−デエチルアモジキノンジ塩酸塩である。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1216894-33-5
Sample solution is provided at 25 µL, 10mM.
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Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References:
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
[2]. Sasi P, et al. In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa. J Infect Dis. 2009 Jun 1;199(11):1575-82.
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