N6-Benzyladenosine-5'-O-diphosphate (sodium salt) |
| カタログ番号GC90800 |
N6-ベンジルアデニンのADP誘導体であり、活性代謝物質。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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N6-Benzyladenosine-5'-O-diphosphate is a derivative of ADP and an active metabolite of the cytokinin N6-benzyladenine .1,2,3 It inhibits the ATPase activities of mortalin, heat shock protein 70 (Hsp70), and heat shock cognate 71 kDa protein (Hsc70; apparent Kis = 86.51, 294.5, and 1,612 µM, respectively, for the human enzymes).2 N6-Benzyladenosine-5'-O-diphosphate inhibits the proliferation of CEM, HL-60, and K562 leukemia, RPMI-8226 multiple myeloma, and MCF-7 breast cancer cells (IC50s = 2, 1.3, 4, 4.5, and 8 µM, respectively).3 It has also been used in the synthesis of radiolabeled and unlabeled forms of N6-benzyladenosine 5'-(γ-thio)-triphosphate (N6-benzyl-ATPγS), which have been used to determine kinase activity.4,5
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