N7-Me-GTP, 100mM Sodium Solution |
カタログ番号GB10790 |
N7-Me-GTPは、5′キャップに共同転写的に追加される正電荷を帯びたメチル修飾GTPです。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
N7-Methylguanosine-5'-triphosphate(N7-Me-GTP, m7G)is a positively charged RNA modification that is co-transcriptionally added to the 5′cap during the initial stages of transcription and prior to other RNA processing events[1]. N7-Me-GTP regulates the transcription, splicing, nuclear export and translation of mRNA, and plays an important role in gene expression, protein synthesis and transcript stability[2]. The N7-Me-GTP modification is also found in tRNA and rRNA, and its presence is associated with various diseases [2].
References:
[1]. Bowen Song, et al. m7GHub: deciphering the location, regulation and pathogenesis of internal mRNA N7-methylguanosine (m7G) sites in human. Bioinformatics, Volume 36, Issue 11, June 2020, Pages 3528-3536.
[2]. Li-Sheng Zhang, et al. Transcriptome-wide Mapping of Internal N7-methylguanosine Methylome in Mammalian Messenger RNA. Published online 2019 Apr 25. DOI:10.1016/j.molcel.2019.03.036.
purity | ≥99% | Extinction Coefficient | |
Formula | C11H18N5O14P3(free acid) | M.Wt | 537.22(free acid) |
Salt Form | 濃度 | ||
Buffer | Storage | -20℃ | |
同義語 | N7- methylguanosine -5'- triphosphate | Backbone | |
Base Analog | Sugar Type | ||
Nucleotide Category |
Average Rating: 5
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