NADP+ (Synonyms: Coenzyme II, β-NADP, Nicotinamide adenine dinucleotide phosphate, TPN) |
| カタログ番号GC44307 |
NADP+は、電子供与体であるニコチンアミドアデニンジヌクレオチドリン酸の酸化型である。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 53-59-8
Sample solution is provided at 25 µL, 10mM.
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NADP+は、電子供与体であるニコチンアミドアデニンジヌクレオチドリン酸の酸化型である。NADP+は還元型のNADPHと共に、レドックスバランスの維持や脂肪酸および核酸の生合成をサポートする役割を担っている。
NADP+は、NAD+の構造アナログであり、ATPからNAD+のアデノシンリボース部分の2'-ヒドロキシル基へのリン酸基の転移によって合成される。この反応はNADキナーゼ（NADKs）によって触媒される。NADP+はさまざまな生物学的反応の補因子として機能する。NADP+/NADPHは、細胞のレドックス状態、エネルギー代謝、ミトコンドリア機能、遺伝子発現、シグナル伝達経路の調節に重要であり、広範な生物学的プロセスを維持するために不可欠である。
References:
[1]. Yang, Yue, and Anthony A. Sauve. "NAD+ metabolism: Bioenergetics, signaling and manipulation for therapy." Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1864.12 (2016): 1787-1800.
[2]. Ying, Weihai. "NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences." Antioxidants & redox signaling 10.2 (2008): 179-206.
[3]. Jackson J B. A review of the binding-change mechanism for proton-translocating transhydrogenase[J]. Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2012, 1817(10): 1839-1846.
[4]. CantÓ, Carles, and Johan Auwerx. "NAD+ as a signaling molecule modulating metabolism." Cold Spring Harbor symposia on quantitative biology. Vol. 76. Cold Spring Harbor Laboratory Press, 2011.
[5]. CantÓ, Carles, Keir J. Menzies, and Johan Auwerx. "NAD+ metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus." Cell metabolism 22.1 (2015): 31-53.
| Cas No. | 53-59-8 | SDF | |
| 同義語 | Coenzyme II, β-NADP, Nicotinamide adenine dinucleotide phosphate, TPN | ||
| Chemical Name | adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'→5'-ester with 3-(aminocarbonyl)-1-β-D-ribofuranosylpyridinium, inner salt | ||
| Canonical SMILES | O[C@H]1[C@@H](OP(O)(O)=O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP(OP(OC[C@@H]4[C@@H](O)[C@@H](O)[C@H]([N+]5=CC(C(N)=O)=CC=C5)O4)([O-])=O)(O)=O | ||
| Formula | C21H28N7O17P3 | M.Wt | 743.4 |
| 溶解度 | Soluble in PBS, PH7.2, 10mg/mL | Storage | Store at -20°C,protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.3452 mL | 6.7259 mL | 13.4517 mL |
| 5 mM | 0.269 mL | 1.3452 mL | 2.6903 mL |
| 10 mM | 0.1345 mL | 0.6726 mL | 1.3452 mL |
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
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Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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