Necrostatin-34 |
| カタログ番号GC62316 |
RIPK1 キナーゼ阻害剤であるネクロスタチン-34 (Nec-34) は、キナーゼ ドメインの異なる結合ポケットを占有することにより、RIPK1 キナーゼを不活性構造に安定化させます 。
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Cas No.: 375835-43-1
Sample solution is provided at 25 µL, 10mM.
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Necrostatin-34 (Nec-34), a RIPK1 kinase inhibitor, stabilizes RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain[1].
Necrostatin-34 (Nec-34) exhibits IC50 values of 667 nM and 134 nM for TNFα in FADD def-Jurkat cells and L939 cells, respectively[1].Necrostatin-34 (Nec-34, 10 μM) inhibits the dimerization-induced RIPK1 activation as examined by phosphorylation of Ser166 (p-S166) of RIPK1, a biomarker for RIPK1 activation[1].Necrostatin-34 (Nec-34) may block TNFα-induced complex II formation by inhibiting the activation of RIPK1 kinase[1].
[1]. Huyan Meng, et al. Discovery of a cooperative mode of inhibiting RIPK1 kinase. Cell Discov. 2021 Jun 1;7(1):41.
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