Nedometinib (Synonyms: NFX-179) |
| カタログ番号GC91576 |
Nedometinib is a MEK1 inhibitor (IC50 = 135 nM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2252314-46-6
Sample solution is provided at 25 µL, 10mM.
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Nedometinib is a MEK1 inhibitor (IC50 = 135 nM).[1] It is selective for MEK1 over a panel of 44 receptors, ion channels, and enzymes at 10 µM, as well as a panel of an additional 150 kinases. Nedometinib (0.1-10 µM) decreases phosphorylation of ERK in malignant peripheral nerve sheath tumor cells. Topical application of nedometinib (0.1-2.3%) reduces the total number of tumors in a mouse model of cutaneous squamous cell carcinoma induced by UV radiation.
References:
[1].Sarin, K.Y., J., K., B., S., et al.Development of a MEK inhibitor, NFX-179, as a chemoprevention agent for squamous cell carcinomaSci. Transl. Med.15(717)(2023).
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