NEO 212 - TMZ-POH |
| カタログ番号GB40295 |
乳がん細胞に対して優れた活性を示す新しいDNAアルキル化剤であり、体内では三重陰性腫瘍の増殖に対しても優れた効果を発揮します（グリオーマ細胞株の細胞毒性IC50値は5-50μM）。NEO 212はDNA損傷と細胞死をより効率的に引き起こすため、POHとの連結によって生物学的半減期が増加し、細胞毒性DNAレッションの配置に大きな機会が提供されます。NEO212はテモゾロミド（TMZ）と天然物ペリリルアルコール（POH）の共役体であり、多くのがん細胞株やグリオームでTMZ耐性を回避します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1361198-79-9
Sample solution is provided at 25 µL, 10mM.
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Novel DNA alkylating agent exhibiting superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo (IC50 values 5-50 µM for cytotoxicity on glioma cell lines). NEO 212 causes DNA damage and cell death much more efficiently than TMZ, because linkage with POH increased its biological half-life and thus provided greater opportunity for placement of cytotoxic DNA lesions.NEO212 is a conjugate of temozolomide (TMZ) with the natural product perillyl alcohol (POH) and circumvents TMZ-resistance in multiple cancer cell lines and gliomas.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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