NF-κB-IN-1 |
| カタログ番号GC62070 |
NF-κB-IN-1、4-アリリデン クルクミン類似体は、強力な NF-κB シグナル伝達経路阻害剤です。 NF-κB-IN-1 は IKK を直接阻害して、NF-κB の活性化をブロックします。 NF-κB-IN-1 は、肺癌細胞の生存率を効果的に阻害し、A549 細胞のクローン形成活性を弱めます。
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Cas No.: 1227098-15-8
Sample solution is provided at 25 µL, 10mM.
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NF-κB-IN-1, a 4-arylidene crucumin analogue, is a potent NF-κB signaling pathway inhibitor. NF-κB-IN-1 directly inhibits IKK to block NF-κB activation. NF-κB-IN-1 effectively inhibits the viability of lung cancer cells and attenuates the clonogenic activity of A549 cells[1].
NF-κB-IN-1 (compound 17) (0.001-100 μM; 72 h) inhibits the growth of A549, H1944, H460 and H157 cells, with GI50s of 0.72, 0.07, 0.13, and 0.16 μM, respectively[1].NF-κB-IN-1 (0.5-25 μM; pretreated for 30 min or 4 h) potently blocks the IκB phosphorylation and degradation in A549 cells[1].NF-κB-IN-1 (0.1-100 μM; pretreated for 30 min) dose-dependently inhibits the TNFα-induced nuclear translocation of NF-κB in A549 cells, with an IC50s of 1.0 μM[1].NF-κB-IN-1 (0.1-0.4 μM; 9 d) inhibits lung cancer clonogenic activity[1].
[1]. Qiu X, et, al. Synthesis and identification of new 4-arylidene curcumin analogues as potential anticancer agents targeting nuclear factor-κB signaling pathway. J Med Chem. 2010 Dec 9;53(23):8260-73.
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