NH2-PEG9-acid |
| カタログ番号GC61969 |
NH2-PEG9-acid は、抗体薬物複合体 (ADC) の合成に使用される非切断型 9 ユニット PEG ADC リンカーです。 NH2-PEG9-acid は、PROTAC の合成に使用できる PEG ベースの PROTAC リンカーでもあります。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 756526-04-2
Sample solution is provided at 25 µL, 10mM.
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NH2-PEG9-acid is a non-cleavable 9 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. NH2-PEG9-acid also is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
[1]. Michael Nathaniel ALONSO, et al. Antibody adjuvant conjugates. WO2018009916A1.
[2]. "An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562."
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