NSC-47924 (Synonyms: 1-((4-Methoxyanilino)methyl)-2-naphthol) |
| カタログ番号GB40301 |
NSC-47924（6638-24-0）は、Leucine-rich repeat protein phosphatase（PHLPP）の強力な阻害剤であり、AktおよびPKCの負の調節因子である酵素です（IC50 = 4μM）。細胞内でAKTシグナルを増加させ、アポトーシスを防止します。また、67 kDaラミニン受容体（LR）とラミニン（LM）の相互作用を抑制し、LR-293細胞がLMに付着することを選択的にブロックします（IC50 = 19.35μM）、細胞移動や浸潤を妨げます。37/67 kDa LR細胞表面局在性および細胞プリオンタンパク質との相互作用に影響を与えます。
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Cas No.: 6638-24-0
Sample solution is provided at 25 µL, 10mM.
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NSC-47924 (6638-24-0) is a potent inhibitor of the Leucine-rich repeat protein phosphatase (PHLPP) an enzyme which is a negative regulator of Akt and PKC (IC50=4 μM). Increases AKT signaling in cells and prevents apoptosis. Also inhibits the 67 kDa laminin receptor (LR) interaction with laminin (LM) and selectively blocks LR-293 cell adhesion to LM (IC50=19.35 μM) impairing cell migration and invasion. Affects 37/67 kDa LR cell surface localization and interaction with cellular prion protein.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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