NU2058 (Synonyms: O6-(Cyclohexylmethyl)guanine) |
| カタログ番号GC19267 |
NU2058 (O6-(シクロヘキシルメチル)グアニン) は、CDK2 および CDK1 に対して 17 μM および 26 μM の IC50 を持つ、強力で競合的なグアニンベースの CDK 阻害剤です。 NU2058 には抗がん作用があります。
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Cas No.: 161058-83-9
Sample solution is provided at 25 µL, 10mM.
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NU2058 is a guanine-based CDK inhibitor with IC50 of 17 uM and 26 uM for CDK2 and CDK1.IC50 value: 17uM (CDK2), 26uM (CDK1)Target: CDKin vitro: NU2058 is a competitive inhibitor of CDK2 with respect to ATP (Ki value CDK2, 12 3 uM) that binds in the ATP binding pocket in a different orientation from other purine-based inhibitors, including olomoucine and roscovotine. NU2058 is the lead compound in a structure-based drug discovery program to develop more potent and selective CDK inhibitors.
References:
[1]. Rigas AC, et al. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer. Oncogene. 2007 Dec 6;26(55):7611-7619.
Average Rating: 5 (Based on Reviews and 20 reference(s) in Google Scholar.)
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