Octyl-α-hydroxyglutarate (Synonyms: Octyl2-HG) |
| カタログ番号GC40287 |
α-ヒドロキシグルタル酸は通常、D-およびL-2-ヒドロキシグルタレートデヒドロゲナーゼによって2-オキソグルタレートに代謝されます。
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Cas No.: 2097068-39-6
Sample solution is provided at 25 µL, 10mM.
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α-Hydroxyglutaric acid is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder. Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2, typically associated with certain cancers, can cause these enzymes to convert isocitrate to 2-HG, rather than α-ketoglutarate. 2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases. Octyl-α-hydroxyglutarate is a cell-permeable derivative of 2-HG.
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