Oleanolic acid (Synonyms: Astrantiagenin C, Caryophyllin, Giganteumgenin C, Gledigenin 1, NSC 114945, Oleanoic Acid, Virgaureagenin B) |
| カタログ番号GN10184 |
Oleanolic acid is a natural pentacyclic triterpenoid known for its effectiveness in treating hepatitis.
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Cas No.: 508-02-1
Sample solution is provided at 25 µL, 10mM.
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Oleanolic acid is a natural pentacyclic triterpenoid known for its effectiveness in treating hepatitis. Additionally, it demonstrates antitumor effects across various types of cancers [1-3].
Oleanolic acid, at concentrations of 50 μM, 65 μM, and 80 μM, when administered for 24 or 48 hours, enhanced the ability of regorafenib to suppress the growth of PLC cells, particularly at doses of 65 μM or 80 μM[4]. Oleanolic acid, at concentrations of 2 μM, 4 μM, and 8 μM administered over 48 hours, acts as an activator of Nrf2. It exhibits a dose-dependent attenuation of TGF-β1-induced epithelial-mesenchymal transition (EMT) in NRK-52E cells [5]. Furthermore, oleanolic acid at a concentration of 50 μM, when applied for 6 hours, induces prostacyclin release in human coronary smooth muscle cells (SMC) through a Cox-2-dependent mechanism[6].
Oleanolic acid(50 mg/kg/d; i.g; 2weeks) exerts anti-EMT effect in vivo and enhances the antitumor effect of regorafenib[4]. Oleanolic acid(10-100 mg/kg; ip) demonstrated significant anti-epileptogenic potential in pentylenetetrazole-induced seizures[7].
References:
[1]. Pollier J, Goossens A. Oleanolic acid. Phytochemistry. 2012 May;77:10-5. doi: 10.1016/j.phytochem.2011.12.022. Epub 2012 Feb 28. PMID: 22377690.
[2]. Ma W, Wang DD, et,al. Caveolin-1 plays a key role in the oleanolic acid-induced apoptosis of HL-60 cells. Oncol Rep. 2014 Jul;32(1):293-301. doi: 10.3892/or.2014.3177. Epub 2014 May 15. PMID: 24842472.
[3]. Žiberna L, Šamec D, et,al. Oleanolic Acid Alters Multiple Cell Signaling Pathways: Implication in Cancer Prevention and Therapy. Int J Mol Sci. 2017 Mar 16;18(3):643. doi: 10.3390/ijms18030643. PMID: 28300756; PMCID: PMC5372655.
[4]. Wang H, Zhong W, et,al. Oleanolic Acid Inhibits Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma by Promoting iNOS Dimerization. Mol Cancer Ther. 2019 Jan;18(1):62-74. doi: 10.1158/1535-7163.MCT-18-0448. Epub 2018 Oct 8. PMID: 30297361.
[5]. He WM, Yin JQ, et,al. Oleanolic acid attenuates TGF-β1-induced epithelial-mesenchymal transition in NRK-52E cells. BMC Complement Altern Med. 2018 Jul 4;18(1):205. doi: 10.1186/s12906-018-2265-y. PMID: 29973206; PMCID: PMC6031099.
[6]. Martínez-González J, Rodríguez-Rodríguez R, et,al. Oleanolic acid induces prostacyclin release in human vascular smooth muscle cells through a cyclooxygenase-2-dependent mechanism. J Nutr. 2008 Mar;138(3):443-8. doi: 10.1093/jn/138.3.443. PMID: 18287347.
[7]. Akünal Türel C, Yunusoğlu O. Oleanolic acid suppresses pentylenetetrazole-induced seizure in vivo. Int J Environ Health Res. 2023 May;33(5):529-540. doi: 10.1080/09603123.2023.2167947. Epub 2023 Feb 22. PMID: 36812380.
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