ONO-8711 (dicyclohexylamine salt) |
| カタログ番号GC90830 |
EP1受容体拮抗剤
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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ONO-8711 is an antagonist of the prostaglandin E2 receptor subtype EP1 (Kis = 0.6 and 1.7 nM for human and mouse receptors, respectively, expressed in CHO cells).1 It is selective for EP1 over EP2, EP3, and EP4 (Kis = >1,000, 67, and >1,000 nM, respectively, for mouse receptors expressed in CHO cells). ONO-8711 inhibits PGE2-induced increases in intracellular calcium concentrations in cells expressing human or mouse EP1 (EC50s = 50 and 210 nM, respectively). Dietary administration of ONO-8711 (400 and 800 ppm) reduces the incidence of squamous cell carcinoma and severe dysplasia in a rat model of tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.2
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